What Is Intrauterine Insemination (IUI)?

Intrauterine insemination (IUI) is a fertility treatment in which laboratory-prepared sperm are transferred directly into a woman’s uterus, allowing the sperm to be closer to the egg and increasing the chance of fertilization.

Unlike in vitro fertilization (IVF), fertilization and embryo development occur naturally inside the body.

🧪 The IUI Process

Step 1: Evaluation & Testing
Your doctor will assess both partners’ fertility status, including hormone levels, fallopian tube patency, and semen quality.

Step 2: Day 2–4 – Ovulation Stimulation
Oral ovulation medications or injectable hormones are used to stimulate follicle development.

Step 3: Day 10–12 – Follicle Monitoring
Ultrasound examinations monitor the size and number of developing follicles.

Step 4: Around Day 14 – Trigger Shot + Sperm Insemination

Sperm Preparation:
After the semen sample is collected, it is washed and concentrated in the laboratory to select viable sperm with better motility.

The processed sperm are then placed directly into the uterine cavity. The procedure is typically quick and does not require anesthesia.

Step 5: Day 15–30 – Progesterone Support
Progesterone is taken as prescribed to support the uterine lining.

Step 6: Day 28–31 – Pregnancy Test
A pregnancy test is performed approximately 14 days after insemination.

👌 Who Is Suitable For IUI?

♀️ Female Factors:

· At least one patent fallopian tube (It is essential as fertilization occurs in the tube)

· Ovulation disorders (e.g., polycystic ovary syndrome or irregular cycles)

· Cervical mucus problems (excessively thick mucus that hinders sperm movement)

· Mild endometriosis

♂️ Male Factors:

· Mild male factor infertility (slightly low sperm count or motility; typically, at least 10 million sperm per cc)

· Sexual dysfunction (e.g., difficulty with ejaculation, retrograde ejaculation, or limited opportunity for intercourse during ovulation)

💓 Success Rate

· Approximately 20% per treatment cycle

· Higher success rates in women under 35

· Usually recommended to try 3–4 cycles

· If pregnancy does not occur after 3–4 attempts, in vitro fertilization (IVF) is often recommended for further treatment.